Cuttlefish retain sharp memory of specific events in old age

The common cuttlefish (Sepia officinalis). Credit: Roger Hanlon
The common cuttlefish (Sepia officinalis). Credit: Roger Hanlon

Cuttlefish can remember what, where, and when specific events happened right up to their last few days of life, researchers have found. The results, published this week in the journal Proceedings of the Royal Society B, are the first evidence of an animal whose memory of specific events does not deteriorate with age.

Researchers from the University of Cambridge, U.K., the Marine Biological Laboratory (MBL), Woods Hole, Mass., and the University of Caen, France, conducted memory tests with 24 common cuttlefish, Sepia Officinalis. Half of them were 10-12 months old not-quite adults, and the other half were 22-24 months old equivalent to humans in their 90s.

first author Alexandra Schnell of the University of Cambridge's Department of Psychology, who conducted the experiments at the Marine Biological Laboratory in collaboration with MBL Senior Scientist Roger Hanlon said, Cuttlefish can remember what they ate, where and when, and use this to guide their feeding decisions in the future. What's surprising is that they don't lose this ability with age, despite showing other signs of aging such as loss of muscle function and appetite.

As humans age, they gradually lose the ability to remember experiences that happened at particular times and places for example, what we had for dinner last Tuesday. This is termed episodic memory, and its decline is thought to be due to the deterioration of a part of the brain called the hippocampus.

Cuttlefish do not have a hippocampus, and their brain structure is dramatically different from ours. The vertical lobe of the cuttlefish brain is associated with learning and memory. This does not deteriorate until the last two to three days of the animal's life, which the researchers say could explain why episodic-like memory is not affected by age in cuttlefish.

To conduct the experiment, the cuttlefish were first trained to approach a specific location in their tank marked with a black and white flag. Then they were trained to learn that two foods they commonly eat grass shrimp, which they prefer, and king prawn were available at specific flag-marked locations and after specific delays. This training was repeated daily for four weeks.

Then the cuttlefishes recall which food would be available, where, and when was tested. To make sure they hadn't just learned a pattern, the two feeding locations were unique each day. All the cuttlefish regardless of age watched which food first appeared at each flag and used that to work out which feeding spot was best at each subsequent mealtime.

Schnell said, the old cuttlefish were just as good as the younger ones in the memory task, in fact, many of the older ones did better in the test phase. We think this ability might help cuttlefish in the wild to remember who they mated with, so they don't go back to the same partner.

Cuttlefish only breed at the end of their life. By remembering who they mated with, where, and how long ago, the researchers think this helps the cuttlefish to spread their genes widely by mating with as many partners as possible.

Cuttlefish have short lifespans most live until around two years old making them a good subject to test whether memory declines with age. Since it is impossible to test whether animals are consciously remembering things, the authors used the term episodic-like memory to refer to the ability of cuttlefish to remember what, where, and when specific things happened.

Journal Information: Episodic-like memory is preserved with age in cuttlefish, Proceedings of the Royal Society B, rspb.royalsocietypublishing.or … .1098/rspb.2021.1052

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