Discovering new cellular mechanisms of bone marrow stem cells

The University of Ulsan Hospital announced on the 29th that the professors of hematology and the Institute of Biomedical Science have discovered a new cell mechanism of bone marrow stem cells that promote differentiation of cartilage, fat, and bone cells.

Professor Jae-cheol Cho, Yoon-sook Choi, Yu-jin Lee, and Ph. It was confirmed that there was a significant increase.

The hospital explained that the light molecule plays an important role in stem cell proliferation and immunity.

Mesenchymal stem cells that can differentiate into cartilage, fat, and bone cells after separation from various tissues such as bone marrow, fat, and umbilical cord are regarded as a promising resource for the treatment of diseases caused by decreased bone density and bone quality.

The hospital expects this discovery to help treat various intractable diseases and bone marrow cancer cells in the future.

The research team also announced that RUNX2/CBFA1, which contributes to bone formation, and proteins such as collagen, alkaline phosphatase, osteox, and osteocalcin, and'WNT/β-catenin cell signaling, activate bone formation differentiation.

Professor Jae-cheol Cho said, as bone marrow-derived stem cells can be used not only for the treatment of osteoporosis and aplastic bone necrosis, but also for various treatment fields, we will be helpful in cell therapy research for blood cancer patients through future research.

This research paper was published in the 2021 issue of the international journal Plos One.

The research team first reported the expression of LIGHT receptor'LTβR' in human bone marrow-derived mesenchymal stem cells, and also published a paper that increases the survival and proliferation of mesenchymal stem cells through the interaction of LIGHT and LTβR.