Researchers evaluate whether lactate sensors can contribute to sports physiology

A Swedish research team's lactate sensor technology undergoes tests. Credit: Gaston Crespo / KTH Royal Institute of Technology
A Swedish research team's lactate sensor technology undergoes tests. Credit: Gaston Crespo / KTH Royal Institute of Technology

While there are a growing number of wearable lactate sensors available for sports and fitness, there hasn't necessarily been an improvement in the understanding of this nascent technology and the debate continues over the usefulness of monitoring lactate in sweat. A recent article in ACS Sensors, a journal of the American Chemical Society, says that despite a recent history of contradictory and incomplete evidence, sports physiology is zeroing in on whether this technology can improve performance while preventing injury.

Co-authors Gaston Crespo and Maria Cuartero, associate and assistant professors at KTH Royal Institute of Technology sid, the promise of lactate sensor technology being able to determine in real-time whether an athlete is exerting themselves too much or too little remains just out of reach for a few basic reasons. There isn't enough evidence about the connection between sports performance and lactate concentration. There is also a lack of understanding about the link between lactate in the sweat and lactate in the bloodstream, as well as the connections with other biomarkers.

Lactate, or lactic acid, is a byproduct of anaerobic respiration when muscle cells convert glucose to energy without oxygen. Sampling athletes' blood helps sports scientists and coaches evaluate an athlete's conditioning and fitness. But the elusive gold standard would be a sensor that monitors lactate in real-time. In the researchers' review of existing research, they point out that are yet no universally-accepted approaches for sweat collection and analysis that provide reliable data for identifying a correlation between sweat lactate and blood lactate. The article offers an analysis of the current state of electrochemical lactate sensors integrated into wearables, and it lists key features to be improved or changed toward the final success of the technology.

Among these is the researchers' own technology, which was published in the same journal during July: An epidermal patch containing a lactate biosensor, as well as pH and temperature sensors. The paper was highlighted in ACS Sensors as one of the journal's most-read articles since its publication.

Temperature and pH typically influence electrochemical readings of lactate, resulting in measurements that are far below what one would expect. So the researchers developed a way to isolate the lactate in sweat using a specially-designed polymer layer in the outer part of the sensor. The polymer protects the reactive enzyme in the sensor from responding to anything but lactate, and it enables the sensor to read higher lactate concentrations than electrochemical sensors typically do. The system's future is two-fold: Commercial and experimental.

Crespo says it is being developed commercially through a new company, IDRO BV, which the researchers founded with a grant from the European Institute of Innovation and Technology (EIT). Furthermore, a collaboration with researchers at Dalarna University in Sweden is using the technology to conduct on-body tests, in which blood and sweat measurements are being correlated with the sport performance of athletes. In addition, sweat samples are being collected for a laboratory-based validation of the sensor performance.

The KTH researchers are collaborating with Dalarna University in Sweden to conduct full-body tests, in which they aim to answer key questions brought up in their recent paper, such as whether lactate production is dependent on active muscles rather than passive ones.

Journal Information: Kevin Van Hoovels et al, Can Wearable Sweat Lactate Sensors Contribute to Sports Physiology?, ACS Sensors (2021). DOI: 10.1021/acssensors.1c01403

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