SpaceX's Crew-2 astronauts will conduct more than 200 science experiments in space


Four astronauts are headed to the International Space Station later this week, where they'll spend six months aboard the orbital outpost conducting research for scientists back on Earth. During their six-month stay, the international crew will conduct more than 200 different research investigations.

NASA astronauts Shane Kimbrough and Megan McArthur, along with European Space Agency (ESA) astronaut Thomas Pesquet and Japan Aerospace Exploration Agency (JAXA) astronaut Akihiko Hoshide, make up the quartet of astronauts that will join the Expedition 65 crew already on board the space station. The astronauts will launch on the Crew-2 mission to the orbiting lab in a SpaceX Crew Dragon spacecraft this Thursday (April 22), and you can watch the launch and prelaunch activities live here on

During their stay, the crew will work on hundreds of experiments, including new medical research. Those experiments will help scientists here on Earth combat diseases and help space agencies around the world better understand how space affects the human body so they can better prepare astronauts for future, longer-duration space travel to the moon.

Among the research investigations, the crew will assist with are several tissue chip experiments. Biomedical researchers have created small systems of cells and tiny organoids that grow on tissue chips and mimic the actions of those cells inside the human body.

The crew will also test a new portable ultrasound device that's designed to help astronauts on long-duration missions to the moon and eventually Mars.

One major goal of the commercial crew program is to launch more astronauts to the station so that NASA is able to do more science. By having a fourth U.S. crew member on the station, NASA says it's able to double the amount of science being conducted at the orbiting lab.

David Brady, the associate program scientist for the International Space Station program at NASA's Johnson Space Center in Houston, said, We didn't want crew time to continue to be the limiting factor on station [in regards to the amount of research being done] ... which is what was happening. The numbers have shown that we are getting the benefits out of having that additional crewmate. Having that extra astronaut has many benefits.

Kirt Costello, the chief scientist for the International Space Station program at NASA Johnson, said that if some crewmembers are busy with other tasks, say an hours-long spacewalk, then time spent doing research investigations would not be lost, as there would be an extra astronaut onboard to devote time to science. More bodies equal more science. We are very glad to have the extra bodies in orbit.

Those extra bodies are great for testing out new systems on the station as well. Recent cargo resupply missions have delivered new environmental systems (like a new toilet, new urine collection system, and water reclamation system) to the station and with an unusually high population on station (11 following the Crew-2 launch), the systems are put to the test.

Costello said, when you're looking at how a system performs, having those extra bodies is a plus. We can't sustain those numbers long-term, but they do provide great data short-term.

Let's take a look at some of the science investigations that the Crew-2 astronauts will perform during their six-month stay in orbit.

Tissue chips contain small groups of cells or tiny organoids that help researchers mimic different kinds of diseases in order to test new treatments or better understand how specific bodily systems respond to spaceflight.

The chips can be incredibly helpful in the drug development process, Lucie Low, a researcher at the National Institutes of Health, said during a prelaunch science briefing on Monday (April 19). Tissue chips are really helpful tools that we can use to try and understand human health and disease.

One tissue chip investigation will look at kidney function, paying close attention to kidney stone formation. The formation of these stones happens very quickly in microgravity and researchers want to understand why.

Another chip investigation will look at the body's immune system. The teams will look at lung function and how the body's immune system responds to microgravity. According to Low, after the past year, this type of research is more important than ever.

Low explained that some of the tissue chip investigations will be testing out drugs and other therapeutics and that the space environment allows researchers to better understand how the cells respond to different therapeutics. One of the things the teams will be looking at is how these drugs affect the very fast cellular changes we see in microgravity. We're going to [hopefully] be able to understand how these drugs work and on a much faster timescale than we could on Earth.

The Crew-2 astronauts are going to continue a tradition that's been carried on by astronauts since humans first went into space photographing the Earth. NASA and other space agencies around the world have a fleet of satellites that are trained to image the planet and measure how it's changing. But only the International Space Station has astronauts that can hold cameras and photograph the Earth from 250 miles (400 kilometers) overhead.

For the past two decades, there's been a continuous human presence on the station, and during that time, astronauts have captured more than 3.5 million images of the Earth, contributing to one of the longest-running records of how Earth has changed over time.

William Stefanov, NASA's ISS Program Scientist for Earth Observations, said, these images are very important, especially for disaster response. It's one of the crew's primary targets.

Stefanov explained that in the case of hurricanes and cyclones, the crew can not only photograph the storm throughout its life cycle but also the areas along a storm's projected path. So officials will have pre-storm imagery, imagery of the storm itself, and then the imagery of the area after the storm passes so that emergency officials can begin to assess the damage.

He said, we've been supporting the international disaster response community in responding to these types of events since 2012.

Another investigation, called CHIME (short for Characterizing Human Immunodeficiency in Microgravity Environments Microgravity), will look more closely at the human immune system and how it responds in microgravity.

Shantanu Jain, a student at New York University Abu Dhabi and lead investigator on the CHIME project, said, The CHIME investigation could help identify potential causes of immune system dysfunction and lead to ways to prevent or counteract it, helping space travelers as well as those with compromised immune systems on Earth. The project, which is sponsored by the United Arab Emirates, will look at how microgravity affects the differentiation of monocytes into macrophages, which are specialized immune system cells. The results could help researchers take steps towards identifying the possible causes for an observed weakened immune response in microgravity.

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